Motrin is a trade name for ibuprofen. It can be administered to both children and adults for providing relief from pain and fever. It is a non – steroidal, anti – pyretic and anti – inflammatory drug that works best against fever, pain and inflammation. It is also proven to be useful for treating pain caused due to dysmenorrhea, rheumatoid arthritis and is indicated in conditions of pericarditis and patent ductus arteriosus. The dosage for motrin will depend on the age of the individual along with the severity of the disease condition. It is important to understand that the drugs should be administered in the right doses, also termed as the therapeutic dose.
All drugs have a specified reaction time, which is called onset of action. It’s the time taken by the drug to have an effect on an individual which is generally 24.5 minutes for motrin, if the drug is taken orally in the form of liquegel. Motrin dosage would also depend on the individual’s body mass and disease condition. The guidelines suggest that a dose of 400mg thrice a day can be taken for over – the – counter use. Under medical conditions, the maximum dosage that is permitted is about 800mg four times a day that amounts to about 3200mg per day. The drug dose may be altered for each patient depending on the onset of the disease condition and also the response to the treatment. Some patients may respond well to low drug doses while for some even as high doses may not be enough to bring about desirable effect.
The dosage of motrin stated above may not always work for patients with rheumatoid arthritis. The drug dosage may need to be altered based on the severity of the symptoms and the patient’s ability to tolerate the level of drug.
In case individuals face any kind of gastrointestinal disturbances with motrin, then we should keep in mind that it should not be taken on an empty stomach and should always be accompanied with meals.
Drug motrin that contains ibuprofen works by inhibiting the action of prostaglandin synthesise. It has also been reported that motrin works well with patients who have mild gastrointestinal disturbances.
The ibuprofen contained in motrin tablets is absorbed at rapid rates. It has been seen that peak levels of serum ibuprofen are reached after 1 – 2 hours of administration of the drug. A strong relationship has been observed between the dosage of motrin and the peak of ibuprofen attained after administration. With doses of 800mg of motrin taken just once, a linear relationship was observed between the drug dose and the peak levels attained. However, this theorem did not seem to work for levels more than 800mg.
No difference was observed in the motrin dosage time profile when the drug motrin was taken on an empty stomach or full stomach. However, it needs special mention here that when motrin was taken soon after meals or on a full stomach, the rate of absorption decreased but not to a significant extent. It can therefore be concluded that the bioavailability of the drug with food is affected the least. The absorption of motrin when taken with antacids that contained aluminum hydroxide and magnesium hydroxide remain unaltered.
Once the action of motrin is completed in the body it is eliminated through the urine. The drug is completely excreted from the body after 24 hours from the last dose. The serum half life of ibuprofen is 1.8 – 2 hours.
When motrin is administered to patients with chronic disease conditions, the effect is seen after several days or weeks. Such patients should regularly keep visiting their doctors for updating the motrin dosage. This is so because, with chronic conditions, the effect of ibuprofen is felt at a later stage and when a desirable level is reached, the doctor should review and adjust the drug dose accordingly. It has been accepted that for mild to moderate pain the dose of motrin should be 400mg, which should be taken every 4 – 6 hours depending on the severity of the pain. For relief from pain it is necessary that the drug be repeated every 4 -6 hours.
Patients with primary dysmenorrhea are administered motrin drug. This is so because, ibuprofen works by decreasing the flow of menstrual blood and also decreases the intrauterine pressure. It also reduces the frequency of uterine contractions thereby providing relief from pain. For this condition, the recommended dose of motrin is 400mg that is repeated every 4 hours.
Availability of The Drug
Motrin is available in the form of tablets in strengths of 400mg, 600mg and 800mg. it is advised that the drug be stored at room temperatures (20 degrees to 25 degrees Celsius) and in dry place.
Dosage of motrin when exceeds 3200mg per day has shown to have the following side effects:
- Gastrointestinal bleeding
- Epigastric pain
- Metabolic acidosis
- Respiratory depression
Under more severe circumstances, it can cause
- Renal failure
- Cardiovascular problems
- Cardiac arrest
- Elevated blood pressure
- Dryness in the eyes, mouth
When motrin dose is under recommended limits, no side effects or adverse reactions have been reported so far. It has been reported that individuals who drink alcohol and consume ibuprofen are at an increased risk of gastrointestinal bleeding. It has also been reported that consumption of ibuprofen over long periods for over 3 months causes erectile dysfunction. The risk of using ibuprofen over prolonged periods has also been associated with onset of cardiovascular thrombotic events, congestive heart failure, edema and renal disease. Motrin tablets cannot be substituted for corticosteroids. They are certainly not meant for treating corticosteroid insufficiency. It is therefore necessary that the individuals with prolonged illness be diagnosed for the specific disease condition and not be treated on motrin alone. Ibuprofen also is known to cause premature closing of ductus arteriosus and therefore pregnant women should not take this drug unless until advised.
Motrin drug is known for its anti – inflammatory, anti pyretic properties and is indicated in patients suffering from fever, pain and chronic illness. The dosage of motrin is devised on the basis of severity of the disease and its clinical symptoms. The normal recommended dose is about 400mg that is needed to be taken 3 – 4 times a day. Motrin gets absorbed well in the blood stream and excess is excreted through the urine. This drug’s action remains unaltered when taken along with antacids. Its action also does not get altered when taken on empty or full stomach. Complete drug removal occurs after a 24 – hour period. More than recommended doses of this drug have found to have adverse effects on health of individuals. In addition long term use of motrin has also found to make home for various underlying medical conditions such as erectile dysfunction and several nervous and cardiac disorders.